Endoscopic treatment of vesicoureteral reflux (VUR) by injection of intra-tissue implant NUBIPLANT™ allows achieving positive results with minimal tissues traumatization, with significantly lesser post-operative complications comparing to open surgery, and with short post-operative period. Operation duration is 10 – 20 min. After operation patient stays in hospital for 1-2 days.

Summary efficiency of VUR treatment by intra-tissue implant NUBIPLANT™ is almost 97%.

Intra-tissue implant NUBIPLANT™ advantages:

- stable clinical effect;
- anatomical integrity preservation of uretero-vesicular segment and its maturation possibility;
- physiological possibility for repeated corrections;
- prevention of pyelonephritis relapse and its severe complications – secondary contracted kidney, nephrogenous hypertension and renal insufficiency;
- prolonged clinical supervision results (up to 7 years);
- more than 500 VUR corrections were made in patients aged from 6 months to 14 years;
- 97% positive result for VUR endoscopic correction.

Table: Endoscopic VUR treatment results using auto-blood, collagen, PAAG Interfal, Esteform, and intra-tissue implant NUBIPLANT™ 12 months after correction.

Endoscopic VUR treatment method by intra-tissue implant NUBIPLANT™ can be completed both in unilateral and in bilateral processes. The method little invasiveness allows to carry out repeated corrections, if needed. Method eliminates severe complication – constantly relapsing pyelonephritis, which leads to secondary contracted kidney, nephrosclerosis and renal function disturbances. Effect is observed immediately after correction and is of stable character. Immediate and summary results of VUR correction in children for non-complicated forms are presented in tables below.

Table: Immediate results of endoscopic VUR correction in children.

Table: Summary results of endoscopic VUR correction in children.

Endoscopic correction indications:

- I-II degree VUR after ineffective conservative therapy during 12-36 months, with frequent pyelonephritis relapses;
- II-IV degree VUR against the background of urinary bladder neurogenic dysfunction with pronounced reflux-nephropathy manifestations and changes in urodynamics indices;
- primary VUR of II-IV degree with renal function disturbance, pronounced urodynamics disturbances and frequent pyelonephritis relapses;
- VUR combined with urethral development abnormalities, such as duplex urethra, its orifice intravesicular ectopia;
- VUR relapse after surgery;
- enuresis.

Contraindications:

- acute pyelonephritis;
- acute cystitis, urethritis.